Nucleotide Regulation of Soluble Guanylate Cyclase Substrate Specificity
نویسندگان
چکیده
منابع مشابه
Regulation of Soluble Guanylate Cyclase Activity
Alterations of the chemical structure of protoporphyrin IX markedly altered the activation of soluble guanylate cyclase purified from bovine lung. Hydrophobic side chains at positions 2 and 4 and vicinal propionic acid residues at positions 6 and 7 of the porphyrin ring (protoporphyrin IX, mesoporphyrin IX) were essential for maximal enzyme activation (K. = 7-8 nM; V, = 6-8 Kmol of cGMP/min/mg)...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2009
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi900696x